Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches. Submitted by jdopazo on Mon, 03/11/2024 - 20:26 Niarakis A, Ostaszewski M, Mazein A, et al. Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches. Front Immunol. 2024;14:1282859. doi:10.3389/fimmu.2023.1282859.
The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery. Submitted by jdopazo on Mon, 03/11/2024 - 20:25 Esteban-Medina M, Loucera C, Rian K, et al. The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery. J Transl Med. 2024;22(1):139. doi:10.1186/s12967-024-04911-7.
Evaluation of a combined detection of SARS-CoV-2 and its variants using real-time allele-specific PCR strategy: an advantage for clinical practice. Submitted by jdopazo on Thu, 01/04/2024 - 12:13 Chaves-Blanco L, de Salazar A, Fuentes A, et al. Evaluation of a combined detection of SARS-CoV-2 and its variants using real-time allele-specific PCR strategy: an advantage for clinical practice. Epidemiol Infect. 2023;151:e201. doi:10.1017/S095026882300184X.
Evidence of the association between increased use of direct oral anticoagulants and a reduction in the rate of atrial fibrillation-related stroke and major bleeding at the population level (2012-2019). Submitted by jdopazo on Fri, 11/24/2023 - 20:17 Loucera C, Carmona R, Bostelmann G, et al. Evidence of the association between increased use of direct oral anticoagulants and a reduction in the rate of atrial fibrillation-related stroke and major bleeding at the population level (2012-2019). Med Clin (Barc). 2023. doi:10.1016/j.medcli.2023.10.008.
Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments. Submitted by jdopazo on Mon, 10/09/2023 - 08:00 Loucera C, Carmona R, Esteban-Medina M, et al. Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments. Virol J. 2023;20(1):226. doi:10.1186/s12985-023-02195-9.
Cell-Level Pathway Scoring Comparison with a Biologically Constrained Variational Autoencoder Submitted by jdopazo on Wed, 09/20/2023 - 13:13 Gundogdu P, Payá-Milans M, Alamo-Alvarez I, Nepomuceno-Chamorro IA, Dopazo J, Loucera C. Cell-Level Pathway Scoring Comparison with a Biologically Constrained Variational Autoencoder. Cham: Springer Nature Switzerland; 2023:62 - 77. doi:10.1007/978-3-031-42697-110.1007/978-3-031-42697-1_5.
A second update on mapping the human genetic architecture of COVID-19. Submitted by jdopazo on Tue, 09/12/2023 - 14:09 A second update on mapping the human genetic architecture of COVID-19. Nature. 2023;621(7977):E7-E26. doi:10.1038/s41586-023-06355-3.
Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Submitted by jdopazo on Tue, 08/15/2023 - 10:27 Pellegrinelli V, Figueroa-Juárez E, Samuelson I, et al. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Rep. 2023;42(6):112640. doi:10.1016/j.celrep.2023.112640.
Visualization of automatically combined disease maps and pathway diagrams for rare diseases. Submitted by jdopazo on Thu, 08/03/2023 - 15:32 Gawron P, Hoksza D, Piñero J, et al. Visualization of automatically combined disease maps and pathway diagrams for rare diseases. Front Bioinform. 2023;3:1101505. doi:10.3389/fbinf.2023.1101505.