SNOW, a web-based tool for the statistical analysis of protein-protein interaction networks

TitleSNOW, a web-based tool for the statistical analysis of protein-protein interaction networks
Publication TypeJournal Article
Year of Publication2009
AuthorsMinguez P, Gotz S, Montaner D, Al-Shahrour F, Dopazo J
Journal TitleNucl. Acids Res.
Volume37
PagesW109-114
Keywordsinteractome, network, snow
Abstract

Understanding the structure and the dynamics of the complex intercellular network of interactions that contributes to the structure and function of a living cell is one of the main challenges of today's biology. SNOW inputs a collection of protein (or gene) identifiers and, by using the interactome as scaffold, draws the connections among them, calculates several relevant network parameters and, as a novelty among the rest of tools of its class, it estimates their statistical significance. The parameters calculated for each node are: connectivity, betweenness and clustering coefficient. It also calculates the number of components, number of bicomponents and articulation points. An interactive network viewer is also available to explore the resulting network. SNOW is available at http://snow.bioinfo.cipf.es.

URLhttp://nar.oxfordjournals.org/content/early/2009/05/19/nar.gkp402.full
DOI10.1093/nar/gkp402