Functional genomics and networks: new approaches in the extraction of complex gene modules.

TitleFunctional genomics and networks: new approaches in the extraction of complex gene modules.
Publication TypeJournal Article
Year of Publication2010
AuthorsMinguez, P, Dopazo, J
JournalExpert Rev Proteomics
Volume7
Issue1
Pagination55-63
Date Published2010 Feb
ISSN1744-8387
KeywordsGene Expression Regulation; Gene Regulatory Networks; Genomics; Protein Binding; Proteins; Systems biology
Abstract

The engine that makes the cell work is made of an intricate network of molecular interactions. Nowadays, the elements and relationships of this complex network can be studied with several types of high-throughput techniques. The dream of having a global picture of the cell from different perspectives that can jointly explain cell behavior is, at least technically, feasible. However, this task can only be accomplished by filling the gap between data and information. The availability of methods capable of accurately managing, integrating and analyzing the results from these experiments is crucial for this purpose. Here, we review the new challenges raised by the availability of different genomic data, as well as the new proposals presented to cope with the increasing data complexity. Special emphasis is given to approaches that explore the transcriptome trying to describe the modules of genes that account for the traits studied.

DOI10.1586/epr.09.103
Alternate JournalExpert Rev Proteomics
PubMed ID20121476