|Title||Evolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Panjkovich, A, Melo, F, Marti-Renom, MA|
ABSTRACT: We introduce a new type of knowledge-based potentials for protein structure prediction, called ’evolutionary potentials’, which are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences. The new potentials have been benchmarked against other knowledge-based potentials, resulting in a significant increase in accuracy for model assessment. In contrast to standard knowledge-based potentials, we propose that evolutionary potentials capture key determinants of thermodynamic stability and specific sequence constraints required for fast folding.
Journal article Genome biology Genome Biol. 2008 Apr 8;9(4):R68.