A comprehensive database for integrated analysis of omics data in autoimmune diseases.

TitleA comprehensive database for integrated analysis of omics data in autoimmune diseases.
Publication TypeJournal Article
Year of Publication2021
AuthorsMartorell-Marugán, J, López-Domínguez, R, García-Moreno, A, Toro-Domínguez, D, Villatoro-García, JAntonio, Barturen, G, Martín-Gómez, A, Troule, K, Gómez-López, G, Al-Shahrour, F, González-Rumayor, V, Peña-Chilet, M, Dopazo, J, Saez-Rodriguez, J, Alarcón-Riquelme, ME, Carmona-Sáez, P
JournalBMC Bioinformatics
Date Published2021 Jun 24
KeywordsAutoimmune Diseases; Computational Biology; Databases, Factual; Humans

BACKGROUND: Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases. Nevertheless, data from different cohorts and pathologies are stored independently in public repositories and a unified resource is imperative to assist researchers in this field.RESULTS: Here, we present Autoimmune Diseases Explorer ( https://adex.genyo.es ), a database that integrates 82 curated transcriptomics and methylation studies covering 5609 samples for some of the most common autoimmune diseases. The database provides, in an easy-to-use environment, advanced data analysis and statistical methods for exploring omics datasets, including meta-analysis, differential expression or pathway analysis.CONCLUSIONS: This is the first omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies.

Alternate JournalBMC Bioinformatics
PubMed ID34167460
PubMed Central IDPMC8223391
Grant ListCV20-36723 / / Consejería de Economía y Conocimiento, Junta de Andalucía /
PI-0173-2017 / / Consejería de Salud, Junta de Andalucía /
GA-115565 / / Innovative Medicines Initiative /