Systems Biology

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.

Submitted by jdopazo on Mon, 03/11/2024 - 20:26

Niarakis A, Ostaszewski M, Mazein A, et al. Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches. Front Immunol. 2024;14:1282859. doi:10.3389/fimmu.2023.1282859.

From genes to functional classes in the study of biological systems.

Submitted by iguillen on Thu, 07/04/2019 - 12:47

Al-Shahrour F, Arbiza L, Dopazo H, et al. From genes to functional classes in the study of biological systems. BMC Bioinformatics. 2007;8:114. doi:10.1186/1471-2105-8-114.

Evidence for systems-level molecular mechanisms of tumorigenesis.

Submitted by iguillen on Thu, 07/04/2019 - 12:45

Hernández P, Huerta-Cepas J, Montaner D, et al. Evidence for systems-level molecular mechanisms of tumorigenesis. BMC Genomics. 2007;8:185. doi:10.1186/1471-2164-8-185.

Functional genomics and networks: new approaches in the extraction of complex gene modules.

Submitted by iguillen on Tue, 06/18/2019 - 13:13

Minguez P, Dopazo J. Functional genomics and networks: new approaches in the extraction of complex gene modules. Expert Rev Proteomics. 2010;7(1):55-63. doi:10.1586/epr.09.103.

Pathway network inference from gene expression data.

Submitted by iguillen on Mon, 06/17/2019 - 12:41

Ponzoni I, Nueda M, Tarazona S, et al. Pathway network inference from gene expression data. BMC Syst Biol. 2014;8 Suppl 2:S7. doi:10.1186/1752-0509-8-S2-S7.

A comparison of mechanistic signaling pathway activity analysis methods.

Submitted by jdopazo on Fri, 11/02/2018 - 11:01

Amadoz A, Hidalgo MR, Cubuk C, Carbonell-Caballero J, Dopazo J. A comparison of mechanistic signaling pathway activity analysis methods. Brief Bioinform. 2019;20(5):1655-1668. doi:10.1093/bib/bby040.