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Gene Expression

Evidence for short-time divergence and long-time conservation of tissue-specific expression after gene duplication.

Submitted by iguillen on Tue, 06/18/2019 - 11:23
Huerta-Cepas J, Dopazo J, Huynen MA, Gabaldón T. Evidence for short-time divergence and long-time conservation of tissue-specific expression after gene duplication. Brief Bioinform. 2011;12(5):442-8. doi:10.1093/bib/bbr022.

Novel genes detected by transcriptional profiling from whole-blood cells in patients with early onset of acute coronary syndrome.

Submitted by iguillen on Tue, 06/18/2019 - 10:26
Silbiger VN, Luchessi AD, Hirata RDC, et al. Novel genes detected by transcriptional profiling from whole-blood cells in patients with early onset of acute coronary syndrome. Clin Chim Acta. 2013;421:184-90. doi:10.1016/j.cca.2013.03.011.

Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin.

Submitted by iguillen on Tue, 06/18/2019 - 10:20
Iglesias JManuel, Beloqui I, Garcia-Garcia F, et al. Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin. PLoS One. 2013;8(10):e77281. doi:10.1371/journal.pone.0077281.

Intrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model.

Submitted by iguillen on Mon, 06/17/2019 - 13:46
González-Tendero A, Torre I, García-Cañadilla P, et al. Intrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model. Am J Physiol Heart Circ Physiol. 2013;305(12):H1752-60. doi:10.1152/ajpheart.00514.2013.

Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity.

Submitted by iguillen on Mon, 06/17/2019 - 12:21
Amadoz A, Sebastián-Leon P, Vidal E, Salavert F, Dopazo J. Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity. Sci Rep. 2015;5:18494. doi:10.1038/srep18494.

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes.

Submitted by iguillen on Mon, 06/10/2019 - 12:01
Hidalgo MR, Cubuk C, Amadoz A, Salavert F, Carbonell-Caballero J, Dopazo J. High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes. Oncotarget. 2017;8(3):5160-5178. doi:10.18632/oncotarget.14107.

Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape.

Submitted by jdopazo on Fri, 11/02/2018 - 11:31
Cubuk C, Hidalgo MR, Amadoz A, et al. Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape. Cancer Res. 2018;78(21):6059-6072. doi:10.1158/0008-5472.CAN-17-2705.

Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome.

Submitted by jdopazo on Fri, 11/02/2018 - 11:02
Hidalgo MR, Amadoz A, Cubuk C, Carbonell-Caballero J, Dopazo J. Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome. Biol Direct. 2018;13(1):16. doi:10.1186/s13062-018-0219-4.