|Lineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes
|Year of Publication
|Gabaldón, T, Huynen, MA
|21 Suppl 2
|Animals Chromosome Mapping/*methods DNA; Mitochondrial/*genetics *Evolution; Molecular *Gene Deletion Genetic Variation/genetics Humans Linkage Disequilibrium/*genetics Mitochondrial Proteins/*genetics Sequence Homology; Nucleic Acid Species Specificity Symbiosis/*genetics
MOTIVATION: The endosymbiotic origin of mitochondria has resulted in a massive horizontal transfer of genetic material from an alpha-proteobacterium to the early eukaryotes. Using large-scale phylogenetic analysis we have previously identified 630 orthologous groups of proteins derived from this event. Here we show that this proto-mitochondrial protein set has undergone extensive lineage-specific gene loss in the eukaryotes, with an average of three losses per orthologous group in a phylogeny of nine species. This gene loss has resulted in a high variability of the alphaproteobacterial-derived gene content of present-day eukaryotic genomes that might reflect functional adaptation to different environments. Proteins functioning in the same biochemical pathway tend to have a similar history of gene loss events, and we use this property to predict functional interactions among proteins in our set.
Gabaldon, Toni Huynen, Martijn A Research Support, Non-U.S. Gov’t England Bioinformatics (Oxford, England) Bioinformatics. 2005 Sep 1;21 Suppl 2:ii144-50.