Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas

TitleIdentification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas
Publication TypeJournal Article
Year of Publication2015
AuthorsLuzón-Toro, B, Bleda, M, Navarro, E, García-Alonso, L, Ruiz-Ferrer, M, Medina, I, Martín-Sánchez, M, Gonzalez, CY, Fernández, RM, Torroglosa, A, Antiňolo, G, Dopazo, J, Borrego, S
JournalBMC Medical Genomics
Volume8
Pagination83
Date PublishedDec
ISSN1755-8794
Abstract

The molecular mechanisms leading to sporadic medullary thyroid carcinoma (sMTC) and juvenile papillary thyroid carcinoma (PTC), two rare tumours of the thyroid gland, remain poorly understood. Genetic studies on thyroid carcinomas have been conducted, although just a few loci have been systematically associated. Given the difficulties to obtain single-loci associations, this work expands its scope to the study of epistatic interactions that could help to understand the genetic architecture of complex diseases and explain new heritable components of genetic risk.

URLhttps://doi.org/10.1186/s12920-015-0160-7
DOI10.1186/s12920-015-0160-7