Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.

TitleHuman DNA methylomes of neurodegenerative diseases show common epigenomic patterns.
Publication TypeJournal Article
Year of Publication2016
AuthorsSanchez-Mut, JV, Heyn, H, Vidal, E, Moran, S, Sayols, S, Delgado-Morales, R, Schultz, MD, Ansoleaga, B, Garcia-Esparcia, P, Pons-Espinal, M, de Lagran, MM, Dopazo, J, Rabano, A, Avila, J, Dierssen, M, Lott, I, Ferrer, I, Ecker, JR, Esteller, M
JournalTransl Psychiatry
Date Published2016 Jan 19
KeywordsAdult; Aged; Aged, 80 and over; DNA Methylation; Epigenomics; Female; Humans; Male; Middle Aged; neurodegenerative diseases; Prefrontal Cortex; Tissue Array Analysis

Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.

Alternate JournalTransl Psychiatry
PubMed ID26784972
PubMed Central IDPMC5068885
Grant ListP50 AG016573 / AG / NIA NIH HHS / United States
HD065160-01 / HD / NICHD NIH HHS / United States
P50-AG16573 / AG / NIA NIH HHS / United States