|Title||Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Fonseca, RF, de Carvalho, FM, Poletta, FA, Montaner, D, Dopazo, J, Mereb, JC, Moreira, MAM, Seuanez, HN, Vieira, AR, Castilla, EE, Orioli, IM|
|Journal||Eur J Oral Sci|
|Date Published||2015 Oct|
The etiology of cleft lip with or without cleft palate (CL±P) is complex and heterogeneous, and multiple genetic and environmental factors are involved. Some candidate genes reported to be associated with oral clefts are located on the X chromosome. At least three genes causing X-linked syndromes [midline 1 (MID1), oral-facial-digital syndrome 1 (OFD1), and dystrophin (DMD)] were previously found to be associated with isolated CL±P. We attempted to confirm the role of X-linked genes in the etiology of isolated CL±P in a South American population through a family-based genome-wide scan. We studied 27 affected children and their mothers, from 26 families, in a Patagonian population with a high prevalence of CL±P. We conducted an exploratory analysis of the X chromosome to identify candidate regions associated with CL±P. Four genomic segments were identified, two of which showed a statistically significant association with CL±P. One is an 11-kb region of Xp21.1 containing the DMD gene, and the other is an intergenic region (8.7 kb; Xp11.4). Our results are consistent with recent data on the involvement of the DMD gene in the etiology of CL±P. The MID1 and OFD1 genes were not included in the four potential CL±P-associated X-chromosome genomic segments.
|Alternate Journal||Eur J Oral Sci|