| Title | Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Goni, JR, Vaquerizas, JM, Dopazo, J, Orozco, M |
| Journal | BMC Genomics |
| Volume | 7 |
| Pagination | 63 |
| Keywords | Animals Base Sequence Computational Biology DNA/chemistry/*genetics/*metabolism Genome; Genetic/genetics Regulatory Sequences; Human/genetics Humans Mice Nucleic Acid Conformation Nucleotides/genetics Oligonucleotides/chemistry/*genetics/*metabolism Promoter Regions; Nucleic Acid/*genetics Transcription Factors/metabolism |
| Abstract | BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome. CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region. |
| Notes | Goni, Josep Ramon Vaquerizas, Juan Manuel Dopazo, Joaquin Orozco, Modesto Research Support, Non-U.S. Gov’t England BMC genomics BMC Genomics. 2006 Mar 27;7:63. |
| URL | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16566817 |
