02177nas a2200313 4500008004100000245013500041210006900176260001500245300001200260490000700272520116700279100003001446700002301476700001901499700002001518700002701538700002701565700002101592700001901613700001601632700002101648700002401669700002401693700002001717700002201737700001801759700002001777856006601797 2004 eng d00aExpression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes.0 aExpression profiling of Tcell lymphomas differentiates periphera c2004 Aug 1 a4971-820 v103 a
PURPOSE: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors. EXPERIMENTAL DESIGN: Using DNA microarrays (CNIO-OncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes. RESULTS: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-kappaB signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found. CONCLUSIONS: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas.
1 aMartinez-Delgado, Beatriz1 aMeléndez, Barbara1 aCuadros, Marta1 aAlvarez, Javier1 aCastrillo, Jose, Maria1 aDe La Parte, Ana, Ruiz1 aMollejo, Manuela1 aBellas, Carmen1 aDiaz, Ramon1 aLombardía, Luis1 aAl-Shahrour, Fatima1 aDomínguez, Orlando1 aCascon, Alberto1 aRobledo, Mercedes1 aRivas, Carmen1 aBenitez, Javier uhttp://clincancerres.aacrjournals.org/content/10/15/4971.long