Sequencing of the SARS-CoV-2 virus genome for the monitoring and management of the Covid-19 epidemic in Andalusia and the rapid generation of prognostic and response to treatment biomarkers

(COVID-0012-2020, funded by the Andalusian COVID-19 Clinical Research Program, Ministry of Health and Families, Andalusian Government)

The differences in the spread, severity of symptoms, mortality and other characteristics of COVID-19 are due to a combination of epidemiological factors, although it is expected that the genetics of the virus will play a very important role, which is still completely unknown.

A consortium, made up of 14 hospitals and 5 Health Research Institutes from the region, the Technical Office for Information Management, the Regional Management of Public Health (Epidemiological Surveillance and Occupational Health Service) and the Fundación Progreso y Salud, intends to use the network of diagnostic centers of the Andalusian community and the sequencing platforms of the Health Research Institutes and associated centers, to sequence about 1,000 samples of the SARS-CoV-2 virus covering the whole of Andalusia obtained from different type of patients (age, sex, previous complications, previous treatments), as well as different clinical profiles observed and responses to treatments.

The genomic data associated with these clinical data, which can be enriched with information from the Andalusian Population Health database, will be used to quickly obtain diagnostic and prognostic biomarkers.

In addition, they will be used to carry out epidemiological monitoring of the disease in real time.

And finally, this project will allow the development of a genomic and clinical Big Data computing resource for future research projects. The project will demonstrate the usefulness of virus genomic sequencing as a real-time translational application tool for this epidemic and others to come.



Previous works and international experience Due to its reduced costs and its accessibility by hospitals, genomic sequencing is considered a valuable tool for healthcare and public health. [...]

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Hypothesis and goals

Differences in spread, incidence, symptoms, and response to drugs may be related to viral genetics, patient genetics or a combination of both [...]

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Epidemiological map

Epidemiological map of SARS-CoV-2 in Andalusia using Nextstrain

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Project achievements will be shown here

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Clinical Bioinformatics Area, Fundación Progreso y Salud.

Edificio C.D.C.A.. Hospital Universitario Virgen del Rocío Avenida Manuel Siurot s/n,

41013 Sevilla, Spain