<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Baz-Redón, Noelia</style></author><author><style face="normal" font="default" size="100%">Sánchez-Bellver, Laura</style></author><author><style face="normal" font="default" size="100%">Fernández-Cancio, Mónica</style></author><author><style face="normal" font="default" size="100%">Rovira-Amigo, Sandra</style></author><author><style face="normal" font="default" size="100%">Burgoyne, Thomas</style></author><author><style face="normal" font="default" size="100%">Ranjit, Rai</style></author><author><style face="normal" font="default" size="100%">Aquino, Virginia</style></author><author><style face="normal" font="default" size="100%">Toro-Barrios, Noemí</style></author><author><style face="normal" font="default" size="100%">Carmona, Rosario</style></author><author><style face="normal" font="default" size="100%">Polverino, Eva</style></author><author><style face="normal" font="default" size="100%">Cols, Maria</style></author><author><style face="normal" font="default" size="100%">Moreno-Galdó, Antonio</style></author><author><style face="normal" font="default" size="100%">Camats-Tarruella, Núria</style></author><author><style face="normal" font="default" size="100%">Marfany, Gemma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel  Variant and Possible Modifier Gene.</style></title><secondary-title><style face="normal" font="default" size="100%">Cells</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cells</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ciliary Motility Disorders</style></keyword><keyword><style  face="normal" font="default" size="100%">Eye Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Genes, Modifier</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Retinitis pigmentosa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024 Mar 16</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We report a novel  missense variant co-segregated with a familial X-linked retinitis pigmentosa (XLRP) case. The brothers were hemizygous for this variant, but only the proband presented with primary ciliary dyskinesia (PCD). Thus, we aimed to elucidate the role of the  variant and other modifier genes in the phenotypic variability observed in the family and its impact on motile cilia. The pathogenicity of the variant on the RPGR protein was evaluated by in vitro studies transiently transfecting the mutated  gene, and immunofluorescence analysis on nasal brushing samples. Whole-exome sequencing was conducted to identify potential modifier variants. In vitro studies showed that the mutated RPGR protein could not localise to the cilium and impaired cilium formation. Accordingly, RPGR was abnormally distributed in the siblings' nasal brushing samples. In addition, a missense variant in  was identified. The concurrent  variant influenced ciliary mislocalisation of the protein. We provide a comprehensive characterisation of motile cilia in this XLRP family, with only the proband presenting PCD symptoms. The variant's pathogenicity was confirmed, although it alone does not explain the respiratory symptoms. Finally, the  gene may be a potential modifier for respiratory symptoms in patients with  mutations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Torrent-Vernetta, Alba</style></author><author><style face="normal" font="default" size="100%">Gaboli, Mirella</style></author><author><style face="normal" font="default" size="100%">Castillo-Corullón, Silvia</style></author><author><style face="normal" font="default" size="100%">Mondéjar-López, Pedro</style></author><author><style face="normal" font="default" size="100%">Sanz Santiago, Verónica</style></author><author><style face="normal" font="default" size="100%">Costa-Colomer, Jordi</style></author><author><style face="normal" font="default" size="100%">Osona, Borja</style></author><author><style face="normal" font="default" size="100%">Torres-Borrego, Javier</style></author><author><style face="normal" font="default" size="100%">de la Serna-Blázquez, Olga</style></author><author><style face="normal" font="default" size="100%">Bellón Alonso, Sara</style></author><author><style face="normal" font="default" size="100%">Caro Aguilera, Pilar</style></author><author><style face="normal" font="default" size="100%">Gimeno-Díaz de Atauri, Álvaro</style></author><author><style face="normal" font="default" size="100%">Valenzuela Soria, Alfredo</style></author><author><style face="normal" font="default" size="100%">Ayats, Roser</style></author><author><style face="normal" font="default" size="100%">Martin de Vicente, Carlos</style></author><author><style face="normal" font="default" size="100%">Velasco González, Valle</style></author><author><style face="normal" font="default" size="100%">Moure González, José Domingo</style></author><author><style face="normal" font="default" size="100%">Canino Calderín, Elisa María</style></author><author><style face="normal" font="default" size="100%">Pastor-Vivero, María Dolores</style></author><author><style face="normal" font="default" size="100%">Villar Álvarez, María Ángeles</style></author><author><style face="normal" font="default" size="100%">Rovira-Amigo, Sandra</style></author><author><style face="normal" font="default" size="100%">Iglesias Serrano, Ignacio</style></author><author><style face="normal" font="default" size="100%">Díez Izquierdo, Ana</style></author><author><style face="normal" font="default" size="100%">de Mir Messa, Inés</style></author><author><style face="normal" font="default" size="100%">Gartner, Silvia</style></author><author><style face="normal" font="default" size="100%">Navarro, Alexandra</style></author><author><style face="normal" font="default" size="100%">Baz-Redón, Noelia</style></author><author><style face="normal" font="default" size="100%">Carmona, Rosario</style></author><author><style face="normal" font="default" size="100%">Camats-Tarruella, Núria</style></author><author><style face="normal" font="default" size="100%">Fernández-Cancio, Mónica</style></author><author><style face="normal" font="default" size="100%">Rapp, Christina</style></author><author><style face="normal" font="default" size="100%">Dopazo, Joaquin</style></author><author><style face="normal" font="default" size="100%">Griese, Matthias</style></author><author><style face="normal" font="default" size="100%">Moreno-Galdó, Antonio</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">ChILD-Spain Group</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Incidence and Prevalence of Children's Diffuse Lung Disease in Spain.</style></title><secondary-title><style face="normal" font="default" size="100%">Arch Bronconeumol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Arch Bronconeumol</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Jan</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">58</style></volume><pages><style face="normal" font="default" size="100%">22-29</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Children's diffuse lung disease, also known as children's Interstitial Lung Diseases (chILD), are a heterogeneous group of rare diseases with relevant morbidity and mortality, which diagnosis and classification are very complex. Epidemiological data are scarce. The aim of this study was to analyse incidence and prevalence of chILD in Spain.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;Multicentre observational prospective study in patients from 0 to 18 years of age with chILD to analyse its incidence and prevalence in Spain, based on data reported in 2018 and 2019.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;A total of 381 cases with chILD were notified from 51 paediatric pulmonology units all over Spain, covering the 91.7% of the paediatric population. The average incidence of chILD was 8.18 (CI 95% 6.28-10.48) new cases/million of children per year. The average prevalence of chILD was 46.53 (CI 95% 41.81-51.62) cases/million of children. The age group with the highest prevalence were children under 1 year of age. Different types of disorders were seen in children 2-18 years of age compared with children 0-2 years of age. Most frequent cases were: primary pulmonary interstitial glycogenosis in neonates (17/65), neuroendocrine cell hyperplasia of infancy in infants from 1 to 12 months (44/144), idiopathic pulmonary haemosiderosis in children from 1 to 5 years old (13/74), hypersensitivity pneumonitis in children from 5 to 10 years old (9/51), and scleroderma in older than 10 years old (8/47).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;We found a higher incidence and prevalence of chILD than previously described probably due to greater understanding and increased clinician awareness of these rare diseases.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record></records></xml>