<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cruz, Raquel</style></author><author><style face="normal" font="default" size="100%">Almeida, Silvia Diz-de</style></author><author><style face="normal" font="default" size="100%">Heredia, Miguel López</style></author><author><style face="normal" font="default" size="100%">Quintela, Inés</style></author><author><style face="normal" font="default" size="100%">Ceballos, Francisco C</style></author><author><style face="normal" font="default" size="100%">Pita, Guillermo</style></author><author><style face="normal" font="default" size="100%">Lorenzo-Salazar, José M</style></author><author><style face="normal" font="default" size="100%">González-Montelongo, Rafaela</style></author><author><style face="normal" font="default" size="100%">Gago-Domínguez, Manuela</style></author><author><style face="normal" font="default" size="100%">Porras, Marta Sevilla</style></author><author><style face="normal" font="default" size="100%">Castaño, Jair Antonio Tenorio</style></author><author><style face="normal" font="default" size="100%">Nevado, Julián</style></author><author><style face="normal" font="default" size="100%">Aguado, Jose María</style></author><author><style face="normal" font="default" size="100%">Aguilar, Carlos</style></author><author><style face="normal" font="default" size="100%">Aguilera-Albesa, Sergio</style></author><author><style face="normal" font="default" size="100%">Almadana, Virginia</style></author><author><style face="normal" font="default" size="100%">Almoguera, Berta</style></author><author><style face="normal" font="default" size="100%">Alvarez, Nuria</style></author><author><style face="normal" font="default" size="100%">Andreu-Bernabeu, Álvaro</style></author><author><style face="normal" font="default" 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size="100%">Brugada, Ramón</style></author><author><style face="normal" font="default" size="100%">Bustos, Matilde</style></author><author><style face="normal" font="default" size="100%">Calderón, Enrique J</style></author><author><style face="normal" font="default" size="100%">Carbonell, Cristina</style></author><author><style face="normal" font="default" size="100%">Castano, Luis</style></author><author><style face="normal" font="default" size="100%">Castelao, Jose E</style></author><author><style face="normal" font="default" size="100%">Conde-Vicente, Rosa</style></author><author><style face="normal" font="default" size="100%">Cordero-Lorenzana, M Lourdes</style></author><author><style face="normal" font="default" size="100%">Cortes-Sanchez, Jose L</style></author><author><style face="normal" font="default" size="100%">Corton, Marta</style></author><author><style face="normal" font="default" size="100%">Darnaude, M Teresa</style></author><author><style face="normal" font="default" size="100%">De Martino-Rodríguez, Alba</style></author><author><style face="normal" font="default" size="100%">Campo-Pérez, Victor</style></author><author><style face="normal" font="default" size="100%">Bustamante, Aranzazu Diaz</style></author><author><style face="normal" font="default" size="100%">Domínguez-Garrido, Elena</style></author><author><style face="normal" font="default" size="100%">Luchessi, André D</style></author><author><style face="normal" font="default" size="100%">Eirós, Rocío</style></author><author><style face="normal" font="default" size="100%">Sanabria, Gladys Mercedes Estigarribia</style></author><author><style face="normal" font="default" size="100%">Fariñas, María Carmen</style></author><author><style face="normal" font="default" size="100%">Fernández-Robelo, Uxía</style></author><author><style face="normal" font="default" size="100%">Fernández-Rodríguez, Amanda</style></author><author><style face="normal" font="default" size="100%">Fernández-Villa, Tania</style></author><author><style face="normal" font="default" size="100%">Gil-Fournier, Belén</style></author><author><style face="normal" font="default" size="100%">Gómez-Arrue, Javier</style></author><author><style face="normal" font="default" size="100%">Álvarez, Beatriz González</style></author><author><style face="normal" font="default" size="100%">Quirós, Fernan Gonzalez Bernaldo</style></author><author><style face="normal" font="default" size="100%">González-Peñas, Javier</style></author><author><style face="normal" font="default" size="100%">Gutiérrez-Bautista, Juan F</style></author><author><style face="normal" font="default" size="100%">Herrero, María José</style></author><author><style face="normal" font="default" size="100%">Herrero-Gonzalez, Antonio</style></author><author><style face="normal" font="default" size="100%">Jimenez-Sousa, María A</style></author><author><style face="normal" font="default" size="100%">Lattig, María Claudia</style></author><author><style face="normal" font="default" size="100%">Borja, Anabel Liger</style></author><author><style face="normal" font="default" size="100%">Lopez-Rodriguez, Rosario</style></author><author><style face="normal" font="default" size="100%">Mancebo, Esther</style></author><author><style face="normal" font="default" size="100%">Martín-López, Caridad</style></author><author><style face="normal" font="default" size="100%">Martín, Vicente</style></author><author><style face="normal" font="default" size="100%">Martinez-Nieto, Oscar</style></author><author><style face="normal" font="default" size="100%">Martinez-Lopez, Iciar</style></author><author><style face="normal" font="default" size="100%">Martinez-Resendez, Michel F</style></author><author><style face="normal" font="default" size="100%">Martinez-Perez, Ángel</style></author><author><style face="normal" font="default" size="100%">Mazzeu, Juliana A</style></author><author><style face="normal" font="default" size="100%">Macías, Eleuterio Merayo</style></author><author><style face="normal" font="default" size="100%">Minguez, Pablo</style></author><author><style face="normal" font="default" size="100%">Cuerda, Victor Moreno</style></author><author><style face="normal" font="default" size="100%">Silbiger, Vivian N</style></author><author><style face="normal" font="default" size="100%">Oliveira, Silviene F</style></author><author><style face="normal" font="default" size="100%">Ortega-Paino, Eva</style></author><author><style face="normal" font="default" size="100%">Parellada, Mara</style></author><author><style face="normal" font="default" size="100%">Paz-Artal, Estela</style></author><author><style face="normal" font="default" size="100%">Santos, Ney P C</style></author><author><style face="normal" font="default" size="100%">Pérez-Matute, Patricia</style></author><author><style face="normal" font="default" size="100%">Perez, Patricia</style></author><author><style face="normal" font="default" size="100%">Pérez-Tomás, M Elena</style></author><author><style face="normal" font="default" size="100%">Perucho, Teresa</style></author><author><style face="normal" font="default" size="100%">Pinsach-Abuin, Mel Lina</style></author><author><style face="normal" font="default" size="100%">Pompa-Mera, Ericka N</style></author><author><style face="normal" font="default" size="100%">Porras-Hurtado, Gloria L</style></author><author><style face="normal" font="default" size="100%">Pujol, Aurora</style></author><author><style face="normal" font="default" size="100%">León, Soraya Ramiro</style></author><author><style face="normal" font="default" size="100%">Resino, Salvador</style></author><author><style face="normal" font="default" size="100%">Fernandes, Marianne R</style></author><author><style face="normal" font="default" size="100%">Rodríguez-Ruiz, Emilio</style></author><author><style face="normal" font="default" size="100%">Rodriguez-Artalejo, Fernando</style></author><author><style face="normal" font="default" 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face="normal" font="default" size="100%">Urioste, Miguel</style></author><author><style face="normal" font="default" size="100%">Valencia-Ramos, Juan</style></author><author><style face="normal" font="default" size="100%">Yáñez, Zuleima</style></author><author><style face="normal" font="default" size="100%">Zarate, Ruth</style></author><author><style face="normal" font="default" size="100%">Nakanishi, Tomoko</style></author><author><style face="normal" font="default" size="100%">Pigazzini, Sara</style></author><author><style face="normal" font="default" size="100%">Degenhardt, Frauke</style></author><author><style face="normal" font="default" size="100%">Butler-Laporte, Guillaume</style></author><author><style face="normal" font="default" size="100%">Maya-Miles, Douglas</style></author><author><style face="normal" font="default" size="100%">Bujanda, Luis</style></author><author><style face="normal" font="default" size="100%">Bouysran, Youssef</style></author><author><style face="normal" font="default" size="100%">Palom, Adriana</style></author><author><style face="normal" font="default" size="100%">Ellinghaus, David</style></author><author><style face="normal" font="default" size="100%">Martínez-Bueno, Manuel</style></author><author><style face="normal" font="default" size="100%">Rolker, Selina</style></author><author><style face="normal" font="default" size="100%">Amitrano, Sara</style></author><author><style face="normal" font="default" size="100%">Roade, Luisa</style></author><author><style face="normal" font="default" size="100%">Fava, Francesca</style></author><author><style face="normal" font="default" size="100%">Spinner, Christoph D</style></author><author><style face="normal" font="default" size="100%">Prati, Daniele</style></author><author><style face="normal" font="default" size="100%">Bernardo, David</style></author><author><style face="normal" font="default" size="100%">García, Federico</style></author><author><style face="normal" font="default" size="100%">Darcis, Gilles</style></author><author><style face="normal" font="default" size="100%">Fernández-Cadenas, Israel</style></author><author><style face="normal" font="default" size="100%">Holter, Jan Cato</style></author><author><style face="normal" font="default" size="100%">Banales, Jesus M</style></author><author><style face="normal" font="default" size="100%">Frithiof, Robert</style></author><author><style face="normal" font="default" size="100%">Duga, Stefano</style></author><author><style face="normal" font="default" size="100%">Asselta, Rosanna</style></author><author><style face="normal" font="default" size="100%">Pereira, Alexandre C</style></author><author><style face="normal" font="default" size="100%">Romero-Gómez, Manuel</style></author><author><style face="normal" font="default" size="100%">Nafría-Jiménez, Beatriz</style></author><author><style face="normal" font="default" size="100%">Hov, Johannes R</style></author><author><style face="normal" font="default" size="100%">Migeotte, Isabelle</style></author><author><style face="normal" font="default" size="100%">Renieri, Alessandra</style></author><author><style face="normal" font="default" size="100%">Planas, Anna M</style></author><author><style face="normal" font="default" size="100%">Ludwig, Kerstin U</style></author><author><style face="normal" font="default" size="100%">Buti, Maria</style></author><author><style face="normal" font="default" size="100%">Rahmouni, Souad</style></author><author><style face="normal" font="default" size="100%">Alarcón-Riquelme, Marta E</style></author><author><style face="normal" font="default" size="100%">Schulte, Eva C</style></author><author><style face="normal" font="default" size="100%">Franke, Andre</style></author><author><style face="normal" font="default" size="100%">Karlsen, Tom H</style></author><author><style face="normal" font="default" size="100%">Valenti, Luca</style></author><author><style face="normal" font="default" size="100%">Zeberg, Hugo</style></author><author><style face="normal" font="default" size="100%">Richards, Brent</style></author><author><style face="normal" font="default" size="100%">Ganna, Andrea</style></author><author><style face="normal" font="default" size="100%">Boada, Mercè</style></author><author><style face="normal" font="default" size="100%">Rojas, Itziar</style></author><author><style face="normal" font="default" size="100%">Ruiz, Agustín</style></author><author><style face="normal" font="default" size="100%">Sánchez, Pascual</style></author><author><style face="normal" font="default" size="100%">Real, Luis Miguel</style></author><author><style face="normal" font="default" size="100%">Guillén-Navarro, Encarna</style></author><author><style face="normal" font="default" size="100%">Ayuso, Carmen</style></author><author><style face="normal" font="default" size="100%">González-Neira, Anna</style></author><author><style face="normal" font="default" size="100%">Riancho, José A</style></author><author><style face="normal" font="default" size="100%">Rojas-Martinez, Augusto</style></author><author><style face="normal" font="default" size="100%">Flores, Carlos</style></author><author><style face="normal" font="default" size="100%">Lapunzina, Pablo</style></author><author><style face="normal" font="default" size="100%">Carracedo, Ángel</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">SCOURGE Cohort Group</style></author><author><style face="normal" font="default" size="100%">HOSTAGE Cohort Group</style></author><author><style face="normal" font="default" size="100%">GRA@CE Cohort Group</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel genes and sex differences in COVID-19 severity.</style></title><secondary-title><style face="normal" font="default" size="100%">Hum Mol Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Hum Mol Genet</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Jun 16</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p &lt; 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (&lt;60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.&lt;/p&gt;</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dopazo, Joaquin</style></author><author><style face="normal" font="default" size="100%">Maya-Miles, Douglas</style></author><author><style face="normal" font="default" size="100%">García, Federico</style></author><author><style face="normal" font="default" size="100%">Lorusso, Nicola</style></author><author><style face="normal" font="default" size="100%">Calleja, Miguel Ángel</style></author><author><style face="normal" font="default" size="100%">Pareja, María Jesús</style></author><author><style face="normal" font="default" size="100%">López-Miranda, José</style></author><author><style face="normal" font="default" size="100%">Rodríguez-Baño, Jesús</style></author><author><style face="normal" font="default" size="100%">Padillo, Javier</style></author><author><style face="normal" font="default" size="100%">Túnez, Isaac</style></author><author><style face="normal" font="default" size="100%">Romero-Gómez, Manuel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System.</style></title><secondary-title><style face="normal" font="default" size="100%">J Pers Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Pers Med</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021 May 26</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/34073493?dopt=Abstract</style></custom1></record></records></xml>