<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fonseca, Renata F</style></author><author><style face="normal" font="default" size="100%">de Carvalho, Flávia M</style></author><author><style face="normal" font="default" size="100%">Poletta, Fernando A</style></author><author><style face="normal" font="default" size="100%">Montaner, David</style></author><author><style face="normal" font="default" size="100%">Dopazo, Joaquin</style></author><author><style face="normal" font="default" size="100%">Mereb, Juan C</style></author><author><style face="normal" font="default" size="100%">Moreira, Miguel A M</style></author><author><style face="normal" font="default" size="100%">Seuanez, Hector N</style></author><author><style face="normal" font="default" size="100%">Vieira, Alexandre R</style></author><author><style face="normal" font="default" size="100%">Castilla, Eduardo E</style></author><author><style face="normal" font="default" size="100%">Orioli, Iêda M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate.</style></title><secondary-title><style face="normal" font="default" size="100%">Eur J Oral Sci</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Eur J Oral Sci</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Oct</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">123</style></volume><pages><style face="normal" font="default" size="100%">381-384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The etiology of cleft lip with or without cleft palate (CL±P) is complex and heterogeneous, and multiple genetic and environmental factors are involved. Some candidate genes reported to be associated with oral clefts are located on the X chromosome. At least three genes causing X-linked syndromes [midline 1 (MID1), oral-facial-digital syndrome 1 (OFD1), and dystrophin (DMD)] were previously found to be associated with isolated CL±P. We attempted to confirm the role of X-linked genes in the etiology of isolated CL±P in a South American population through a family-based genome-wide scan. We studied 27 affected children and their mothers, from 26 families, in a Patagonian population with a high prevalence of CL±P. We conducted an exploratory analysis of the X chromosome to identify candidate regions associated with CL±P. Four genomic segments were identified, two of which showed a statistically significant association with CL±P. One is an 11-kb region of Xp21.1 containing the DMD gene, and the other is an intergenic region (8.7 kb; Xp11.4). Our results are consistent with recent data on the involvement of the DMD gene in the etiology of CL±P. The MID1 and OFD1 genes were not included in the four potential CL±P-associated X-chromosome genomic segments.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/26331285?dopt=Abstract</style></custom1></record></records></xml>