<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Martinez-Delgado, Beatriz</style></author><author><style face="normal" font="default" size="100%">Meléndez, Barbara</style></author><author><style face="normal" font="default" size="100%">Cuadros, Marta</style></author><author><style face="normal" font="default" size="100%">Alvarez, Javier</style></author><author><style face="normal" font="default" size="100%">Castrillo, Jose Maria</style></author><author><style face="normal" font="default" size="100%">Ruiz De La Parte, Ana</style></author><author><style face="normal" font="default" size="100%">Mollejo, Manuela</style></author><author><style face="normal" font="default" size="100%">Bellas, Carmen</style></author><author><style face="normal" font="default" size="100%">Diaz, Ramon</style></author><author><style face="normal" font="default" size="100%">Lombardía, Luis</style></author><author><style face="normal" font="default" size="100%">Fatima Al-Shahrour</style></author><author><style face="normal" font="default" size="100%">Domínguez, Orlando</style></author><author><style face="normal" font="default" size="100%">Cascon, Alberto</style></author><author><style face="normal" font="default" size="100%">Robledo, Mercedes</style></author><author><style face="normal" font="default" size="100%">Rivas, Carmen</style></author><author><style face="normal" font="default" size="100%">Benitez, Javier</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes.</style></title><secondary-title><style face="normal" font="default" size="100%">Clinical cancer research : an official journal of the American Association for Cancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004 Aug 1</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://clincancerres.aacrjournals.org/content/10/15/4971.long</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">4971-82</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;PURPOSE: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors. EXPERIMENTAL DESIGN: Using DNA microarrays (CNIO-OncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes. RESULTS: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-kappaB signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found. CONCLUSIONS: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas.&lt;/p&gt;</style></abstract></record></records></xml>