TY - JOUR T1 - Functional interpretation of microarray experiments JF - OMICS Y1 - 2006 A1 - Dopazo, J. KW - babelomics KW - Diabetes Mellitus KW - microarray data analysis AB -

Over the past few years, due to the popularisation of high-throughput methodologies such as DNA microarrays, the possibility of obtaining experimental data has increased significantly. Nevertheless, the interpretation of the results, which involves translating these data into useful biological knowledge, still remains a challenge. The methods and strategies used for this interpretation are in continuous evolution and new proposals are constantly arising. Initially, a two-step approach was used in which genes of interest were initially selected, based on thresholds that consider only experimental values, and then in a second, independent step the enrichment of these genes in biologically relevant terms, was analysed. For different reasons, these methods are relatively poor in terms of performance and a new generation of procedures, which draw inspiration from systems biology criteria, are currently under development. Such procedures, aim to directly test the behaviour of blocks of functionally related genes, instead of focusing on single genes.

VL - 10 UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17069516 N1 -

Dopazo, Joaquin Research Support, Non-U.S. Gov’t United States Omics : a journal of integrative biology OMICS. 2006 Fall;10(3):398-410.

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