02090nas a2200169   4500008004100000245011600041210006900157300000900226490000600235520123000241653007701471653008501548653014401633100001801777700001901795856010601814       2007                        eng d00aFrom endosymbiont to host-controlled organelle: the hijacking of mitochondrial protein synthesis and metabolism0 aFrom endosymbiont to hostcontrolled organelle the hijacking of m  ae2190 v33 aMitochondria are eukaryotic organelles that originated from the endosymbiosis of an alpha-proteobacterium. To gain insight into the evolution of the mitochondrial proteome as it proceeded through the transition from a free-living cell to a specialized organelle, we compared a reconstructed ancestral proteome of the mitochondrion with the proteomes of alpha-proteobacteria as well as with the mitochondrial proteomes in yeast and man. Overall, there has been a large turnover of the mitochondrial proteome during the evolution of mitochondria. Early in the evolution of the mitochondrion, proteins involved in cell envelope synthesis have virtually disappeared, whereas proteins involved in replication, transcription, cell division, transport, regulation, and signal transduction have been replaced by eukaryotic proteins. More than half of what remains from the mitochondrial ancestor in modern mitochondria corresponds to translation, including post-translational modifications, and to metabolic pathways that are directly, or indirectly, involved in energy conversion. Altogether, the results indicate that the eukaryotic host has hijacked the proto-mitochondrion, taking control of its protein synthesis and metabolism.10aComputer Simulation DNA Mutational Analysis/methods Evolution *Evolution10aGenetic Organelles/physiology Protein Biosynthesis/*genetics Symbiosis/*genetics10aMolecular Fungal Proteins/*physiology Genetic Variation/genetics Humans Mitochondria/*physiology Mitochondrial Proteins/*physiology *Models1 aGabaldón, T.1 aHuynen, M., A.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17983265