01509nas a2200169   4500008004100000245009800041210006900139260001300208300001100221490000700232520088300239100002201122700003201144700002001176700002201196856012101218       2011                        eng d00aPhylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1.0 aPhylogenetic and in silico structural analysis of the Parkinson   c2011 Apr  a369-780 v323 a<p>Parkinson disease (PD) is the second most common neurodegenerative disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Mutations in PINK1 were shown to cause recessive familial PD, and today are proposed to be associated with the disease via mitochondrial dysfunction and oxidative damage. The PINK1 gene comprises eight exons, which encode a ubiquitously expressed 581 amino acid protein that contains an N-terminal mitochondrial targeting domain and a serine/threonine protein kinase. To better understand the relationship between PINK1 and PD we have first analyzed the evolutionary history of the gene showing its late emergence in evolution. In addition, we have modeled the three-dimensional structure of PINK1 and found some evidences that help to explain the effect of some PD-related mutations in this protein’s function.</p>1 aCardona, Fernando1 aSánchez-Mut, Jose, Vicente1 aDopazo, Hernán1 aPérez-Tur, Jordi  uhttp://clinbioinfosspa.es/content/phylogenetic-and-silico-structural-analysis-parkinson-disease-related-kinase-pink1