01787nas a2200181   4500008004100000245012500041210006900166300001300235490001500248520091200263653004401175653003901219653014701258653005701405100001801462700001901480856010601499       2005                        eng d00aLineage-specific gene loss following mitochondrial endosymbiosis and its potential for function prediction in eukaryotes0 aLineagespecific gene loss following mitochondrial endosymbiosis   aii144-500 v21 Suppl 23 aMOTIVATION: The endosymbiotic origin of mitochondria has resulted in a massive horizontal transfer of genetic material from an alpha-proteobacterium to the early eukaryotes. Using large-scale phylogenetic analysis we have previously identified 630 orthologous groups of proteins derived from this event. Here we show that this proto-mitochondrial protein set has undergone extensive lineage-specific gene loss in the eukaryotes, with an average of three losses per orthologous group in a phylogeny of nine species. This gene loss has resulted in a high variability of the alphaproteobacterial-derived gene content of present-day eukaryotic genomes that might reflect functional adaptation to different environments. Proteins functioning in the same biochemical pathway tend to have a similar history of gene loss events, and we use this property to predict functional interactions among proteins in our set.10aAnimals Chromosome Mapping/*methods DNA10aMitochondrial/*genetics *Evolution10aMolecular *Gene Deletion Genetic Variation/genetics Humans Linkage Disequilibrium/*genetics Mitochondrial Proteins/*genetics Sequence Homology10aNucleic Acid Species Specificity Symbiosis/*genetics1 aGabaldón, T.1 aHuynen, M., A.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16204094