01696nas a2200193   4500008004100000245009300041210006900134300001000203490000600213520105200219653001501271100001401286700001701300700002401317700001601341700002401357700001501381856010601396       2007                        eng d00aFunctional profiling and gene expression analysis of chromosomal copy number alterations0 aFunctional profiling and gene expression analysis of chromosomal  a432-50 v13 a<p>Contrarily to the traditional view in which only one or a few key genes were supposed to be the causative factors of diseases, we discuss the importance of considering groups of functionally related genes in the study of pathologies characterised by chromosomal copy number alterations. Recent observations have reported the existence of regions in higher eukaryotic chromosomes (including humans) containing genes of related function that show a high degree of coregulation. Copy number alterations will consequently affect to clusters of functionally related genes, which will be the final causative agents of the diseased phenotype, in many cases. Therefore, we propose that the functional profiling of the regions affected by copy number alterations must be an important aspect to take into account in the understanding of this type of pathologies. To illustrate this, we present an integrated study of DNA copy number variations, gene expression along with the functional profiling of chromosomal regions in a case of multiple myeloma.</p>10ababelomics1 aConde, L.1 aMontaner, D.1 aBurguet-Castell, J.1 aTarraga, J.1 aAl-Shahrour, Fatima1 aDopazo, J.  uhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17597935