@article {902,
	title = {Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group.},
	journal = {Evolutionary bioinformatics online},
	volume = {8},
	year = {2012},
	month = {2012},
	pages = {89-104},
	abstract = {Previous comparative genomic studies of genes involved in olfactory behavior in Drosophila focused only on particular gene families such as odorant receptor and/or odorant binding proteins. However, olfactory behavior has a complex genetic architecture that is orchestrated by many interacting genes. In this paper, we present a comparative genomic study of olfactory behavior in Drosophila including an extended set of genes known to affect olfactory behavior. We took advantage of the recent burst of whole genome sequences and the development of powerful statistical tools to analyze genomic data and test evolutionary and functional hypotheses of olfactory genes in the six species of the Drosophila melanogaster species group for which whole genome sequences are available. Our study reveals widespread purifying selection and limited incidence of positive selection on olfactory genes. We show that the pace of evolution of olfactory genes is mostly independent of the life cycle stage, and of the number of life cycle stages, in which they participate in olfaction. However, we detected a relationship between evolutionary rates and the position that the gene products occupy in the olfactory system, genes occupying central positions tend to be more constrained than peripheral genes. Finally, we demonstrate that specialization to one host does not seem to be associated with bursts of adaptive evolution in olfactory genes in D. sechellia and D. erecta, the two specialists species analyzed, but rather different lineages have idiosyncratic evolutionary histories in which both historical and ecological factors have been involved.},
	issn = {1176-9343},
	doi = {10.4137/EBO.S8484},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273929/?tool=pubmed},
	author = {Lavagnino, Nicol{\'a}s and Serra, Fran{\c c}ois and Arbiza, Leonardo and Dopazo, Hern{\'a}n and Hasson, Esteban}
}
@article {22026421,
	title = {Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments.},
	journal = {Environmental microbiology},
	year = {2011},
	month = {2011 Oct 26},
	abstract = {<p>The synthesis of di-myo-inositol phosphate (DIP), a common compatible solute in hyperthermophiles, involves the consecutive actions of inositol-1-phosphate cytidylyltransferase (IPCT) and di-myo-inositol phosphate phosphate synthase (DIPPS). In most cases, both activities are present in a single gene product, but separate genes are also found in a few organisms. Genes for IPCT and DIPPS were found in the genomes of 33 organisms, all with thermophilic/hyperthermophilic lifestyles. Phylogeny of IPCT/DIPPS revealed an incongruent topology with 16S RNA phylogeny, thus suggesting horizontal gene transfer. The phylogenetic tree of the DIPPS domain was rooted by using phosphatidylinositol phosphate synthase sequences as out-group. The root locates at the separation of genomes with fused and split genes. We propose that the gene encoding DIPPS was recruited from the biosynthesis of phosphatidylinositol. The last DIP-synthesizing ancestor harboured separated genes for IPCT and DIPPS and this architecture was maintained in a crenarchaeal lineage, and transferred by horizontal gene transfer to hyperthermophilic marine Thermotoga species. It is plausible that the driving force for the assembly of those two genes in the early ancestor is related to the acquired advantage of DIP producers to cope with high temperature. This work corroborates the view that Archaea were the first hyperthermophilic organisms.</p>},
	doi = {10.1111/j.1462-2920.2011.02621.x},
	author = {Gon{\c c}alves, Lu{\'\i}s G and Borges, Nuno and Serra, Fran{\c c}ois and Fernandes, Pedro L and Dopazo, Hern{\'a}n and Santos, Helena}
}
