@article {17983265,
	title = {From endosymbiont to host-controlled organelle: the hijacking of mitochondrial protein synthesis and metabolism},
	journal = {PLoS Comput Biol},
	volume = {3},
	number = {11},
	year = {2007},
	note = {Gabaldon, Toni Huynen, Martijn A Research Support, Non-U.S. Gov{\textquoteright}t United States PLoS computational biology PLoS Comput Biol. 2007 Nov;3(11):e219. Epub 2007 Sep 26.},
	pages = {e219},
	abstract = {Mitochondria are eukaryotic organelles that originated from the endosymbiosis of an alpha-proteobacterium. To gain insight into the evolution of the mitochondrial proteome as it proceeded through the transition from a free-living cell to a specialized organelle, we compared a reconstructed ancestral proteome of the mitochondrion with the proteomes of alpha-proteobacteria as well as with the mitochondrial proteomes in yeast and man. Overall, there has been a large turnover of the mitochondrial proteome during the evolution of mitochondria. Early in the evolution of the mitochondrion, proteins involved in cell envelope synthesis have virtually disappeared, whereas proteins involved in replication, transcription, cell division, transport, regulation, and signal transduction have been replaced by eukaryotic proteins. More than half of what remains from the mitochondrial ancestor in modern mitochondria corresponds to translation, including post-translational modifications, and to metabolic pathways that are directly, or indirectly, involved in energy conversion. Altogether, the results indicate that the eukaryotic host has hijacked the proto-mitochondrion, taking control of its protein synthesis and metabolism.},
	keywords = {Computer Simulation DNA Mutational Analysis/methods Evolution *Evolution, Genetic Organelles/physiology Protein Biosynthesis/*genetics Symbiosis/*genetics, Molecular Fungal Proteins/*physiology Genetic Variation/genetics Humans Mitochondria/*physiology Mitochondrial Proteins/*physiology *Models},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=PubMed\&dopt=Citation\&list_uids=17983265},
	author = {Gabald{\'o}n, T. and M. A. Huynen}
}
