@inbook {473,
	title = {Comparative genomics-based prediction of protein function},
	booktitle = {Methods in Molecular Biology},
	volume = {439},
	year = {2008},
	publisher = {M. Starkey and R. Elaswarapu, Humana press},
	organization = {M. Starkey and R. Elaswarapu, Humana press},
	url = {http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-59745-188-8_26},
	author = {Gabald{\'o}n, T.}
}
@inbook {472,
	title = {The core of a minimal gene set: insights from natural reduced genomes},
	booktitle = {Protocells: Bridging nonliving and living matter},
	year = {2008},
	pages = {347-366},
	publisher = {The MIT Press},
	organization = {The MIT Press},
	address = {USA},
	author = {Gabald{\'o}n, T. and Gil, R. and Peret{\'o}, J. and Latorre, A. and Moya, A.}
}
@article {16870830,
	title = {Computational approaches for the prediction of protein function in the mitochondrion},
	journal = {Am J Physiol Cell Physiol},
	volume = {291},
	number = {6},
	year = {2006},
	note = {Gabaldon, Toni Research Support, Non-U.S. Gov{\textquoteright}t Review United States American journal of physiology. Cell physiology Am J Physiol Cell Physiol. 2006 Dec;291(6):C1121-8. Epub 2006 Jul 26.},
	pages = {C1121-8},
	abstract = {Understanding a complex biological system, such as the mitochondrion, requires the identification of the complete repertoire of proteins targeted to the organelle, the characterization of these, and finally, the elucidation of the functional and physical interactions that occur within the mitochondrion. In the last decade, significant developments have contributed to increase our understanding of the mitochondrion, and among these, computational research has played a significant role. Not only general bioinformatics tools have been applied in the context of the mitochondrion, but also some computational techniques have been specifically developed to address problems that arose from within the mitochondrial research field. In this review the contribution of bioinformatics to mitochondrial biology is addressed through a survey of current computational methods that can be applied to predict which proteins will be localized to the mitochondrion and to unravel their functional interactions.},
	keywords = {*Computational Biology *Computer Simulation Humans Mitochondria/*metabolism Mitochondrial Proteins/genetics/*metabolism Mutation},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=PubMed\&dopt=Citation\&list_uids=16870830},
	author = {Gabald{\'o}n, T.}
}
@article {15670813,
	title = {Combining data from genomes, Y2H and 3D structure indicates that BolA is a reductase interacting with a glutaredoxin},
	journal = {FEBS Lett},
	volume = {579},
	number = {3},
	year = {2005},
	note = {Huynen, Martijn A Spronk, Chris A E M Gabaldon, Toni Snel, Berend Research Support, Non-U.S. Gov{\textquoteright}t Netherlands FEBS letters FEBS Lett. 2005 Jan 31;579(3):591-6.},
	pages = {591-6},
	abstract = {Genomes, functional genomics data and 3D structure reflect different aspects of protein function. Here, we combine these data to predict that BolA, a widely distributed protein family with unknown function, is a reductase that interacts with a glutaredoxin. Comparisons at the 3D structure level as well as at the sequence profile level indicate homology between BolA and OsmC, an enzyme that reduces organic peroxides. Complementary to this, comparative analyses of genomes and genomics data provide strong evidence of an interaction between BolA and the mono-thiol glutaredoxin family. The interaction between BolA and a mono-thiol glutaredoxin is of particular interest because BolA does not, in contrast to its homolog OsmC, have evolutionarily conserved cysteines to provide it with reducing equivalents. We propose that BolA uses the mono-thiol glutaredoxin as the source for these.},
	keywords = {*Genome Glutaredoxins Models, Molecular Oxidoreductases/chemistry/*metabolism Phylogeny Protein Conformation},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=PubMed\&dopt=Citation\&list_uids=15670813},
	author = {M. A. Huynen and Spronk, C. A. and Gabald{\'o}n, T. and B. Snel}
}
